期刊
EXPERIMENTAL CELL RESEARCH
卷 333, 期 2, 页码 238-248出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2015.03.005
关键词
HOTAIR; Serous ovarian cancer; Proliferation; Cell cycle; Apoptosis
资金
- National Natural Science Foundation of China [81370689]
- Shanghai Science and Technology Development Funds for the Talents [15YF1401400]
HOX transcript antisense RNA (HOTAIR) is a well-known long non-coding RNA (IncRNA) whose dysregulation correlates with poor prognosis and malignant progression in many forms of cancer. Here, we investigate the expression pattern, clinical significance, and biological function of HOTAIR in serous ovarian cancer (SOC). Clinically, we found that HOTAIR levels were overexpressed in SOC tissues compared with normal controls and that HOTAIR overexpression was correlated with an advanced FIGO stage and a high histological grade. Multivariate analysis revealed that HOTAIR is an independent prognostic factor for predicting overall survival in SOC patients. We demonstrated that HOTAIR silencing inhibited A2780 and OVCA429 SOC cell proliferation in vitro and that the anti-proliferative effects of HOTAIR silencing also occurred in vivo. Further investigation into the mechanisms responsible for the growth inhibitory effects by HOTAIR silencing revealed that its knockdown resulted in the induction of cell cycle arrest and apoptosis through certain cell cycle-related and apoptosis-related proteins. Together, these results highlight a critical role of HOTAIR in SOC cell proliferation and contribute to a better understanding of the importance of dysregulated IncRNAs in SOC progression. (C) 2015 Elsevier Inc. All rights reserved.
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