期刊
EXPERIMENTAL CELL RESEARCH
卷 333, 期 2, 页码 183-189出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2014.11.010
关键词
Lysophosphatidic acid; LPA; Autotaxin; ATX; LysoPLD; cancer; metastasis
资金
- INSERM
- University of Lyon
- Comite Departemental de la Loire de la Ligue Contre le Cancer
- French Association pour la Recherche sur le Cancer, ARC
- Ligue Nationale contre le Cancer
Lysophosphatidic acid (LPA) is a simple lipid with a single fatty acyl chain linked to a glycerophosphate backbone. Despite the simplicity of its structure but owing to its interactions with a series of at least six G protein-coupled receptors (LPA(1-6)), LPA exerts pleiotropic bioactivities including stimulation of proliferation, migration and survival of many cell types. Autotaxin (ATX) is a unique enzyme with a lysophospholipase D (lysoPLD) activity that is responsible for the levels of LPA in the blood circulation. Both LPA receptor family members and ATX/LysoPLD are aberrantly expressed in many human cancers. This review will present the more striking as well as novel experimental evidences using cell lines, cancer mouse models and transgenic animals identifying the roles for ATX and LPA receptors in cancer progression, tumor cell invasion and metastasis. (C) 2014 Elsevier Inc. All rights reserved.
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