期刊
ADVANCED MATERIALS
卷 30, 期 29, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201801198
关键词
biodegradable mesoporous silica nanoparticles; cancer-cell-membrane cloaking; diselenide; dual-responsive; protein delivery
类别
资金
- National Natural Science Foundation of China [81601609, 81771982, 61535010, 81371681, 8160071152]
- NIH [HL109442, AI096305, 1UG3TR002142, GM110494]
- Guangdong Innovative and Entrepreneurial Research Team Program [2013S086]
- Global Research Laboratory Program (Korean NSF GRL) [2015032163]
- National Key Research and Development Program of China [2017YFF0108600, 2016YFF0103800]
- National Research Foundation of Korea [2015K1A1A2032163] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Controlled delivery of protein therapeutics remains a challenge. Here, the inclusion of diselenide-bond-containing organosilica moieties into the framework of silica to fabricate biodegradable mesoporous silica nanoparticles (MSNs) with oxidative and redox dual-responsiveness is reported. These diselenide-bridged MSNs can encapsulate cytotoxic RNase A into the 8-10 nm internal pores via electrostatic interaction and release the payload via a matrix-degradation controlled mechanism upon exposure to oxidative or redox conditions. After surface cloaking with cancer-cell-derived membrane fragments, these bioinspired RNase A-loaded MSNs exhibit homologous targeting and immune-invasion characteristics inherited from the source cancer cells. The efficient in vitro and in vivo anti-cancer performance, which includes increased blood circulation time and enhanced tumor accumulation along with low toxicity, suggests that these cell-membrane-coated, dual-responsive degradable MSNs represent a promising platform for the delivery of bio-macromolecules such as protein and nucleic acid therapeutics.
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