期刊
ADVANCED MATERIALS
卷 30, 期 35, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201802808
关键词
nanoassembly; photodynamic therapy; pH-responsive; theranostics; upconversion nanoparticle
类别
资金
- National Key Research and Development Program of China [2016YFA0203600]
- National Natural Science Foundation of China [51503180, 51703195, 51611540345]
- Thousand Talents Program for Distinguished Young Scholars [588020*G81501/048]
- Fundamental Research Funds for the Central Universities [520002*172210161]
- Research Center Program for the Institute of Basic Science in Korea [IBS-R006-D1]
- Ministry of Science & ICT (MSIT), Republic of Korea [IBS-R006-D1-2018-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Upconversion nanoparticle (UCNP)-mediated photodynamic therapy has shown great effectiveness in increasing the tissue-penetration depth of light to combat deep-seated tumors. However, the inevitable phototoxicity to normal tissues resulting from the lack of tumor selectivity remains as a major challenge. Here, the development of tumor-pH-sensitive photodynamic nanoagents (PPNs) comprised of self-assembled photosensitizers grafted pH-responsive polymeric ligands and UCNPs is reported. Under neutral pH conditions, photosensitizers aggregated in the PPNs are self-quenched; however, upon entry into a tumor microenvironment with lower pH, the PPNs not only exhibit enhanced tumor-cell internalization due to charge reversal but also are further disassembled into well-dispersed nanoparticles in the endo/lysosomes of tumor cells, enabling the efficient activation of photosensitizers. The results demonstrate the attractive properties of both UCNP-mediated deep-tissue penetration of light and high therapeutic selectivity in vitro and in vivo.
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