期刊
ADVANCED MATERIALS
卷 30, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201706856
关键词
aggregation-induced emission; blood-brain barrier; cancer; deep brain penetration
类别
资金
- National Basic Research Program of China (973 Program) [2013CB834701, 2013CB834704]
- National Natural Science Foundation of China [61275190]
- Zhejiang Provincial Natural Science Foundation of China [LR17F050001]
- University Grants Committee of Hong Kong [AoE/P-03/08]
- Research Grants Council of Hong Kong [16305015, 16308016, N-HKUST604/14]
- Innovation and Technology Commission [ITC-CNERC14SC01, ITCPD117-9]
- Science and Technology Plan of Shenzhen [JCYJ20160229205601482]
Fluorescence imaging in the spectral region beyond the conventional near-infrared biological window (700-900 nm) can theoretically afford high resolution and deep tissue penetration. Although some efforts have been devoted to developing a short-wave infrared (SWIR; 900-1700 nm) imaging modality in the past decade, long-wavelength biomedical imaging is still suboptimal owing to the unsatisfactory materials properties of SWIR fluorophores. Taking advantage of organic dots based on an aggregation-induced emission luminogen (AIEgen), herein microscopic vasculature imaging of brain and tumor is reported in living mice in the SWIR spectral region. The long-wavelength emission of AIE dots with certain brightness facilitates resolving brain capillaries with high spatial resolution (approximate to 3 mu m) and deep penetration (800 mu m). Owning to the deep penetration depth and real-time imaging capability, in vivo SWIR microscopic angiography exhibits superior resolution in monitoring blood-brain barrier damage in mouse brain, and visualizing enhanced permeability and retention effect in tumor sites. Furthermore, the AIE dots show good biocompatibility, and no noticeable abnormalities, inflammations or lesions are observed in the main organs of the mice. This work will inspire new insights on development of advanced SWIR techniques for biomedical imaging.
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