期刊
ADVANCED MATERIALS
卷 30, 期 27, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201800069
关键词
artificial enzymes; catalysis; molecular imprinting technology; organophosphorus; porous aromatic frameworks
类别
资金
- National Basic Research Programme of China (973 Programme) [2012CB821700, 2014CB931800]
- National Natural Science Foundation of China (NSFC) [21401069, 21501024, 21604008, 91622106]
- Major International (Regional) Joint Research Project of NSFC [21120102034]
Artificially designed enzymes are in demand as ideal catalysts for industrial production but their dense structure conceals most of their functional fragments, thus detracting from performance. Here, molecularly imprinted porous aromatic frameworks (MIPAFs) which are exploited to incorporate full host-guest interactions of porous materials within the artificial enzymes are presented. By decorating a porous skeleton with molecularly imprinted complexes, it is demonstrated that MIPAFs are porous artificial enzymes possessing excellent kinetics for guest molecules. In addition, due to the abundance of accessible sites, MIPAFs can perform a wide range of sequential processes such as substrate hydrolysis and product transport. Through its two functional sites in tandem, the MIPAF subsequently manifests both hydrolysis and transport behaviors. Advantageously, the obtained catalytic rate is approximate to 58 times higher than that of all other conventional artificial enzymes and even surpasses by 14 times the rate for natural organophosphorus hydrolase (Flavobacterium sp. strain ATCC 27551).
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