期刊
ADVANCED MATERIALS
卷 30, 期 27, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201800512
关键词
brain imaging; contrast agents; in vivo imaging; indocyanine green; ultrasound
类别
资金
- Defense Advanced Research Projects Agency (DARPA) [HR0011-13-2-0017]
- National Science Foundation [CBET-1603177]
- National Institutes of Health [R01 AI132413-01]
- UCSD Frontiers of Innovation Scholars Program (FISP) fellowship
- Ministry of Education [2017R1C1B5075766]
- Ministry of Science and ICT [NRF-2017R1E1A1A01074847]
- NIH [DP2 HL137187, R00 HL117048]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R00HL117048, DP2HL137187] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI132413] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [S10OD021821] Funding Source: NIH RePORTER
Photoacoustic (PA) imaging allows visualization of the physiology and pathology of tissues with good spatial resolution and relatively deep tissue penetration. The method converts near-infrared (NIR) laser excitation into thermal expansion, generating pressure transients that are detected with an acoustic transducer. Here, we find that the response of the PA contrast agent indocyanine green (ICG) can be enhanced 17-fold when it is sealed within a rigid nanoparticle. ICG encapsulated in particles composed of porous silicon (pSiNP), porous silica, or calcium silicate all show greater PA contrast relative to equivalent quantities of free ICG, with the pSiNPs showing the strongest enhancement. A liposomal formulation of ICG performs similar to free ICG, suggesting that a rigid host nanostructure is necessary to enhance ICG performance. The improved response of the nanoparticle formulations is attributed to the low thermal conductivity of the porous inorganic hosts and their ability to protect the ICG payload from photolytic and/or thermal degradation. The translational potential of ICG-loaded pSiNPs as photoacoustic probes is demonstrated via imaging of a whole mouse brain.
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