期刊
ADVANCED MATERIALS
卷 30, 期 7, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201704833
关键词
cancer target; chemotherapy; hypoxia; lanthanide-doped mesoporous nanoparticles; photodynamic therapy
类别
资金
- National Key R&D Program of China [2017YFA0207303]
- National Science Fund for Distinguished Young Scholars [21725502]
- Key Basic Research Program of Science and Technology Commission of Shanghai Municipality [17JC1400100]
Tumor hypoxia is typically presented in the central region of solid tumors, which is mainly caused by an inadequate blood flow and oxygen supply. In the conventional treatment of hypoxic human tumors, not only the oxygen-dependent photodynamic therapy (PDT), but also antitumor drug-based chemotherapy, is considerably limited. The use of direct oxygen delivering approach with oxygen-dependent PDT or chemotherapy may potentiate the reactive oxygen species (ROS)-mediated cytotoxicity of the drug toward normal tissues. Herein, a synergetic one-for-all mesoporous cerium oxide upconversion biophotocatalyst is developed to achieve intratumorally endogenous H2O2-responsive self-sufficiency of O-2 and near-infrared light controlled PDT simultaneously for overcoming hypoxia cancer. Furthermore, the sufficient O-2 plays an important role in overcoming the chemotherapeutic drug-resistant cancer caused by hypoxia, therefore inducing tumor cell apoptosis significantly.
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