期刊
ADVANCED MATERIALS
卷 30, 期 28, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201800634
关键词
arrays; fluorescent polymers; liver fibrosis; multichannels; point of care
类别
资金
- Royal Society International Exchange Grant
- EPSRC [EP/M506448/1]
- University of Glasgow
- UCLH NIHR Biomedical Research Centre
- NIH [GM077173]
Liver disease is the fifth most common cause of premature death in the Western world, with the irreversible damage caused by fibrosis, and ultimately cirrhosis, a primary driver of mortality. Early detection of fibrosis would facilitate treatment of the underlying liver disease to limit progression. Unfortunately, most cases of liver disease are diagnosed late, with current strategies reliant on invasive biopsy or fragile lab-based antibody technologies. A robust, fully synthetic fluorescent-polymer sensor array is reported, which, rapidly (in 45 minutes), detects liver fibrosis from low-volume serum samples with clinically relevant specificity and accuracy, using an easily readable diagnostic output. The simplicity, rapidity, and robustness of this method make it a promising platform for point-of-care diagnostics for detecting and monitoring liver disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据