期刊
ADVANCED MATERIALS
卷 30, 期 14, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201707196
关键词
3D cell culture; cancer; electrospinning; microtissue; tissue engineering
类别
资金
- NIH's Physical Sciences-Oncology Network through a UO1 grant [U01 CA210152-01A1]
- NIH's Microfluidics in Biomedical Sciences Training Program: NIH NIBIB [T32 EB005582]
- National Science Foundation Graduate Research Fellowship Program [DGE 1256260]
- Department of Defense Breast Cancer Research Post-Doctoral Fellowship [W81XWH-10-1-0582]
- NIH/NCRR [S10RR026475-01]
- NATIONAL CANCER INSTITUTE [U01CA210152, R00CA198929] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR026475] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [T32EB005582] Funding Source: NIH RePORTER
The advent of adaptive manufacturing techniques supports the vision of cellinstructive materials that mimic biological tissues. 3D jet writing, a modified electrospinning process reported herein, yields 3D structures with unprecedented precision and resolution offering customizable pore geometries and scalability to over tens of centimeters. These scaffolds support the 3D expansion and differentiation of human mesenchymal stem cells in vitro. Implantation of these constructs leads to the healing of critical bone defects in vivo without exogenous growth factors. When applied as a metastatic target site in mice, circulating cancer cells home in to the osteogenic environment simulated on 3D jet writing scaffolds, despite implantation in an anatomically abnormal site. Through 3D jet writing, the formation of tessellated microtissues is demonstrated, which serve as a versatile 3D cell culture platform in a range of biomedical applications including regenerative medicine, cancer biology, and stem cell biotechnology.
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