期刊
ADVANCED FUNCTIONAL MATERIALS
卷 28, 期 18, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201707496
关键词
deep-tissue; low-dose X-ray; nanoplatforms; photodynamic therapy; W(VI)-doped persistent luminescence nanoparticles
类别
资金
- National Natural Science Foundation of China [21622502, 21475026, 21505021, 21605023]
- Natural Science Foundation of Fujian Province of China [2015H6011, 2016J05035, 2017J06004]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT15R11]
- outstanding youth scientific research personnel training plan of colleges and universities in Fujian Province
- Health-Education joint research project of Fujian Province [WKJ2016-2-23]
- Independent Research Project of State Key Laboratory of Photocatalysis on Energy and Environment [2014B02]
- Major State Basic Research Development Program of China [2017YFA0205201, 2014CB744503]
Although photodynamic therapy (PDT) has served as an important strategy for treatment of various diseases, it still experiences many challenges, such as shallow penetration of light, high-dose light irradiation, and low therapy efficiency in deep tissue. Here, a low-dose X-ray-activated persistent luminescence nanoparticle (PLNP)-mediated PDT nanoplatform for depth-independent and repeatable cancer treatment has been reported. In order to improve therapeutic efficiency, this study first synthesizes W(VI)-doped ZnGa2O4:Cr PLNPs with stronger persistent luminescence intensity and longer persistent luminescence time than traditional ZnGa2O4:Cr PLNPs. The proposed PLNPs can serve as a persistent excitation light source for PDT, even after X-ray irradiation has been removed. Both in vitro and in vivo experiments demonstrate that low-dose (0.18Gy) X-ray irradiation is sufficient to activate the PDT nanoplatform and causes significant inhibitory effect on tumor progression. Therefore, such PDT nanoplatform will provide a promising depth-independent treatment mode for clinical cancer therapy in the future.
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