期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 240, 期 3, 页码 351-360出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370214566558
关键词
WW domain; protein domain repeats; peptide-mediated interactions; WW domain containing oxidoreductase; Yes-associated protein; cooperative binding; regulation of signaling
资金
- European Research Council [310873]
- European Research Council (ERC) [310873] Funding Source: European Research Council (ERC)
Interactions mediated by short linear motifs in proteins play major roles in regulation of cellular homeostasis since their transient nature allows for easy modulation. We are still far from a full understanding and appreciation of the complex regulation patterns that can be, and are, achieved by this type of interaction. The fact that many linear-motif-binding domains occur in tandem repeats in proteins indicates that their mutual communication is used extensively to obtain complex integration of information toward regulatory decisions. This review is an attempt to overview, and classify, different ways by which two and more tandem repeats cooperate in binding to their targets, in the well-characterized family of WW domains and their corresponding polyproline ligands.
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