期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 240, 期 6, 页码 752-759出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370215579162
关键词
Parkinson's disease; leucine-rich repeat kinase 2; gene-environment interaction
资金
- Michael J. Fox Foundation
- National Institute of Environmental Health Sciences at the National Institutes of Health [R00ES019879, R03ES022819]
Interactions between genetic and environmental factors are thought to contribute to the pathogenesis of the majority of Parkinson's disease (PD) cases. However, our understanding of these interactions is at an early stage. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of hereditary PD. Penetrance of LRRK2 mutations is incomplete and variable, suggesting that other environmental or genetic factors may contribute to the development of the disorder. Recently, using animal models, several attempts have been made to understand if LRRK2 may mediate sensitivity to environmental neurotoxicants. Here, we critically review the most current data on how LRRK2 mutations influence neurotoxicity in PD models.
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