期刊
ADVANCED FUNCTIONAL MATERIALS
卷 28, 期 25, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201706410
关键词
DNA origami; dynamic light scattering; nanomachines; surface-enhanced fluorescence; thermo-responsive polymers
类别
资金
- UK EPSRC [EP/G060649/1, EP/L015978/1, EP/L027151/1]
- ERC [LINASS320503]
- Dr. Manmohan Singh scholarship from St. John's College
- EPSRC [EP/L027151/1, EP/G060649/1] Funding Source: UKRI
Nanomachines capable of controlled programmable work at the nanoscale promise to revolutionize a vast range of research and eventually should impact on daily lives. Due to the ease of design and modification, DNA origami is emerging as a natural platform to build such machines. However, one essential challenge is the controlled and rapid actuation of DNA origami using an external biocompatible stimulus. Here, actuation based on temperature-induced phase transitions of the thermo-responsive polymer poly(N-isopropylacrylamide) (PNIPAM) is reported. By incorporating this polymer into DNA origami structures on either side of a flexible region, a DNA origami flexor is created that uses the tunable PNIPAM hydrophobicity to reversibly open and close the DNA structures. Such a mechanism has the advantage of being versatile and biocompatible, and possessing strong response to temperature changes of a few degrees Kelvin.
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