期刊
ADVANCED FUNCTIONAL MATERIALS
卷 28, 期 33, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201802159
关键词
cancer therapy; drug release; magnetic resonance imaging; nanoparticles
类别
资金
- NIH/NCI [R01CA199668]
- NIH/NICHD [R01HD086195]
- UC Davis Comprehensive Cancer Center Support Grant (CCSG) by the National Cancer Institute [NCI P30CA093373]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD086195] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R01CA199668, R01CA232845, P30CA093373] Funding Source: NIH RePORTER
Monitoring of in vivo drug release from nanotheranostics by noninvasive approaches remains very challenging. Herein, novel redox-responsive polymeric magnetosomes (PolyMags) with tunable magnetic resonance imaging (MRI) properties are reported for in vivo drug release monitoring and effective dual-modal cancer therapy. The encapsulation of doxorubicin (DOX) significantly decreases PolyMags' T-2-contrast enhancement and transverse relaxation rate R-2, depending on the drug loading level. The T-2 enhancement and R-2 can be recovered once the drug is released upon PolyMags' disassembly. T-2-and T-2*-MRI and diffusion-weighted imaging (DWI) are utilized to quantitatively study the correlation between MRI signal changes and drug release, and discover the MR tuning mechanisms. The in vivo drug release pattern is visualized based on such tunable MRI capability via monitoring the changes in T-2-weighted images, T-2 and T-2* maps, and R-2 and R-2* values. Interestingly, the PolyMags possess excellent photothermal effect, which can be further enhanced upon DOX loading. The PolyMags are highly efficacious to treat breast tumors on xenograft model with tumor-targeted photothermal and chemotherapy, achieving a complete cure rate of 66.7%. The concept reported here is generally applicable to other micellar and liposomal systems for image-guided drug delivery and release applications toward precision cancer therapy.
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