期刊
ADVANCED FUNCTIONAL MATERIALS
卷 28, 期 31, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201801139
关键词
cancer; chemotherapy; degradable nanosheets; photothermal therapy; telluride molybdenum
类别
资金
- National Natural Science Foundation of China [51690152, 21721005]
Telluride molybdenum (MoTe2) nanosheets with wide near-infrared (NIR) absorbance are functionalized with polyethylene glycol-cyclic arginine-glycine-aspartic acid tripeptide (PEG-cRGD). After loading a chemotherapeutic drug (doxorubicin, DOX), MoTe2-PEG-cRGD/DOX is used for combined photothermal therapy and chemotherapy. With the high photothermal conversion efficiency, MoTe2-PEG-cRGD/DOX exhibits favorable cells killing ability under NIR irradiation. Owing to the cRGD-mediated specific tumor targeting, MoTe2-PEG-cRGD/DOX shows efficient accumulation in tumors to induce a strong tumor ablation effect. MoTe2-PEG-cRGD nanosheets, which are relatively stable in the circulation, could be degraded under NIR ray. The in vitro and in vivo experimental results demonstrate that this theranostic nanoagent, which could accumulate in tumors to allow photothermal imaging and combined therapy, is readily degradable in normal organs to enable rapid excretion and avoid long-term retention/toxicity, holding great potential to treat tumor effectively.
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