期刊
ADVANCED FUNCTIONAL MATERIALS
卷 28, 期 21, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201705708
关键词
bacterial trapping; biocompatible and recyclable; nonchemotherapic antibacterial nanoagents; photothermal/magnetic dual-responsive; wound disinfection
类别
资金
- National Natural Science Foundation of China [51503125, 51673125, 51773127]
- State Key Research Development Programme of China [2016YFC1103000, 2016YFC1103001]
- Youth Science and Technology Innovation Team of Sichuan Province [2015TD0001]
- DRS POINT Fellowship of Freie Universitat Berlin
- Alexander von Humboldt Fellowship
- China Scholarship Council (CSC)
Recent emerged antibacterial agents provide enormous new possibilities to replace antibiotics in fighting bacterial infectious diseases. Although abundant types of nanoagents are developed for preventing pathogen colonization, however, rationally design of nonchemotherapic, robust, and clinical-adaptable nanoagents with tunable bacterial trap and killing activities remains a major challenge. Here, a demonstration of controlling the trap, ablation, and release activities of pathogenic bacteria via stimulus-responsive regulatory mechanism is reported. First, temperature-sensitive polymer brush is chemically grown onto carbon nanotube-Fe3O4, whereby the synthesized nanoagents can transfer from hydrophilic dispersion to hydrophobic aggregation upon near-infrared light irradiation, which thus controls the bacterial trap, killing, and detaching. In turn, the formed aggregations will serve as localized heating sources to enhance photothermal ablation of bacteria. Systematically antibacterial experiments and mouse wound disinfection demonstrate the ultrarobust and recyclable disinfection capability of nanoagents with nearly 100% killing ratio to Staphylococcus aureus. Overall, for the first time, we represent a pioneering study on designing nonchemotherapic and robust dual-responsive nanoagents that can sensitively and reversibly trap, inactivate, and detach bacteria. We envision that such nanoagents will not only have potential applications in pathogenic bacteria prevention but also provide a new pathway for wound disinfection, implant sterilization, and also live bacteria transportation.
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