期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 240, 期 8, 页码 1099-1106出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370215591828
关键词
Mesenchymal stem cells; hematopoietic stem cell; niche; aging; biased differentiation; bone remodeling; osteoporosis
资金
- National Key Scientific Program [2012CB966901, 2014CB942900]
- Natural Science Foundation of China [81130039, 81421061]
- Program of Shanghai Subject Chief Scientist [13XD1401900]
The aging population and the incidence of aging-related diseases such as osteoporosis are on the rise. Aging at the tissue and organ levels usually involves tissue stem cells. Human and animal model studies indicate that aging affects two aspects of mesenchymal stem cell (MSC): a decrease in the bone marrow MSC pool and biased differentiation into adipocyte at the cost of osteoblast, which underlie the etiology of osteoporosis. Aging of MSC cells is also detrimental to some non-skeletal tissues, in particular the hematopoietic system, where MSCs serve as a niche component. In addition, aging compromises the therapeutic potentials of MSC cells, including cells isolated from aged individuals or cells cultured for many passages. Here we discuss the recent progress on our understanding of MSC aging, with a focus on the effects of MSC aging on bone remodeling and hematopoiesis and the mechanisms of MSC aging.
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