期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 130, 期 -, 页码 113-130出版社
ELSEVIER
DOI: 10.1016/j.addr.2018.07.009
关键词
GLP-1 receptor agonist; Exenatide; Peptide delivery; Half-life; Pharmacokinetics; Fatty acid conjugate; Albumin fusion; Fc fusion
资金
- NIH [HL134569, T32 GM008353, T32 HL125242]
- Amneal Pharmaceuticals [N023714-00]
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) belong to an important therapeutic class for treatment of type 2 diabetes. Six GLP-1 RAs, each utilizing a unique drug delivery strategy, are now approved by the Food and Drug Administration (FDA) and additional, novel GLP-1 RAs are still under development, making for a crowded marketplace and fierce competition among the manufacturers of these products. As rapid elimination is a major challenge for clinical application of GLP-1 RAs, various half-life extension strategies have been successfully employed including sequential modification, attachment of fatty-acid to peptide, fusion with human serum albumin, fusion with the fragment crystallizable (Fc) region of a monoclonal antibody, sustained drug delivery systems, and PEGylation. In this review, we discuss the scientific rationale of the various half-life extension strategies used for GLP-1 RA development. By analyzing and comparing different approved GLP-1 RAs and those in development, we focus on assessing how half-life extending strategies impact the pharmacokinetics, pharmacodynamics, safety, patient usability and ultimately, the commercial success of GLP-1 RA products. We also anticipate future GLP-1 RA development trends. Since similar drug delivery strategies are also applied for developing other therapeutic peptides, we expect this case study of GLP-1 RAs will provide generalizable concepts for the rational design of therapeutic peptides products with extended duration of action. (C) 2018 Elsevier B.V. All rights reserved.
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