期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 146, 期 -, 页码 190-208出版社
ELSEVIER
DOI: 10.1016/j.addr.2018.06.002
关键词
Biomaterials scaffolds; Controlled delivery system; Skin tissue regeneration; Molecular engineering; Extracellular matrix; Glycosaminoglycan-protein interaction; Therapeutic angiogenesis
资金
- National Science Foundation of China [51503232]
- Fundo para o Desenvolvimento das Ciencias e da Tecnologia, Macau [FDCT 126/2016/A3]
- University of Macau [MYRG2017-00028-ICMS]
- State Key Laboratory of Natural Medicines (Chinese Pharmaceutical University) [SKLNMKF201805]
Growth factors (GFs) are versatile signalling molecules that orchestrate the dynamic, multi-stage process of wound healing. Delivery of exogenous GFs to the wound milieu to mediate healing in an active, physiologically-relevant manner has shown great promise in laboratories; however, the inherent instability of GFs, accompanied with numerous safety, efficacy and cost concerns, has hindered the clinical success of GF delivery. In this article, we highlight that the key to overcoming these challenges is to enhance the control of the activities of GFs throughout the delivering process. We summarise the recent strategies based on biomaterials matrices and molecular engineering, which aim to improve the conditions of GFs for delivery (at the 'supply' end of the delivery), increase the stability and functions of GFs in extracellular matrix (in transportation to target cells), as well as enhance the GFs/receptor interaction on the cell membrane (at the 'destination' end of the delivery). Many of these investigations have led to encouraging outcomes in various in vitro and in vivo regenerative models with considerable translational potential. (C) 2018 Elsevier B.V. All rights reserved.
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