期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 128, 期 -, 页码 29-53出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2018.04.001
关键词
Microfluidics; Drug delivery; Nanotechnology; Nanomedicine; Organ-on-a-chip; 3D culture
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [NRF-2015R1A2A1A09005662, 2016R1A4A1010796]
- American Heart Association National Scientist Development Grant [15SDG25080314]
- National Science Foundation CAREER award [CMMI 1653006]
Microfluidic technologies employ nano and microscale fabrication techniques to develop highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead compounds can be produced with the controlled physicochemical properties, characterized in a high-throughput fashion, and evaluated in in vitro biomimetic models of human organs; organ-on-a-chip. As a step forward from conventional in vitro culture methods, microfluidics shows promise in effective preclinical testing of nanoparticle-based drug delivery. This review presents a curated selection of state-of-the-art microfluidic platforms focusing on the fabrication, characterization, and assessment of nanoparticles for drug delivery applications. We also discuss the current challenges and future prospects of nanoparticle drug delivery development using microfluidics. (C) 2018 Published by Elsevier B.V.
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