期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 131, 期 -, 页码 3-21出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2018.05.002
关键词
Nanocrystals; Co-crystals; Drug; Top-down; Bottom-up; Milling; Homogenization; Microfluidics; Supercritical fluids; Spray dryer
资金
- Finnish Cultural Foundation [00170202]
- University of Helsinki Research Funds
- HiLIFE Research Funds
- Sigrid Juselius Foundation [4704580]
- European Research Council under the European Union [310892]
- European Research Council (ERC) [310892] Funding Source: European Research Council (ERC)
The use of drug nanocrystals in the drug formulation is increasing due to the large number of poorly water-soluble drug compounds synthetized and due to the advantages brought by the nanonization process. The downsizing processes are done using a top-down approach (milling and homogenization currently employed at the industrial level), while the crystallization process is performed by bottom-up techniques (e.g., antisolvent precipitation, use of supercritical fluids or spray and freeze drying). In addition, the production of nanocrystals in confined environment can be achieved within microfluidics channels. This review analyzes the processes for the preparation of nanocrystals and co-crystals, divided by top-down and bottom-up approaches, together with their combinations. The combination of both strategies merges the favorable features of each process and avoids the disadvantages of single processes. Overall, the applicability of drug nanocrystals is highlighted by the widespread research on the production processes at the engineering, pharmaceutical, and nanotechnology level. (C) 2018 Elsevier B.V. All rights reserved.
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