期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 129, 期 -, 页码 285-294出版社
ELSEVIER
DOI: 10.1016/j.addr.2018.01.010
关键词
Regenerative medicine; Extracellular matrix; Extracellular vesicles; Mesenchymal stem cells; Immunomodulation; Inflammation; Bone repair; Paracrine factors; Tissue engineering
资金
- People Programme (Marie Curie Actions) of the European Union 7th Framework Programme under REA (iTERM) [607868]
- Swiss National Science Foundation [NBM 1579]
- Italian Ministry of Health [GR-2013-323 02357519]
Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing. Innovative strategies to enhance bone repair, including the delivery of osteoprogenitor cells or of potent cytokines/morphogens, indicate the potential of 'orthobiologics', but are not fully satisfactory. Here, we review different approaches based on the delivery of regenerative cues produced by cells but in cell-free, possibly off-the-shelf configurations. Such strategies exploit the paracrine effect of the secretome of mesenchymal stem/stromal cells, presented in soluble form, shuttled through extracellular vesicles, or embedded within the network of extracellular matrix molecules. In addition to osteoinductive molecules, attention is given to factors targeting the resident immune cells, to reshape inflammatory and immunity processes from scarring to regenerative patterns. (C) 2018 Elsevier B.V. All rights reserved.
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