期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 129, 期 -, 页码 407-419出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2018.02.002
关键词
Extracellular matrix (ECM); Wound healing; Fibrosis; Tissue engineering
资金
- Whitaker International Program, Institute of International Education, United States of America
- Swedish Research Council [VR 4-478/2016]
- UK Regenerative Medicine Platform Acellular Approaches for Therapeutic Delivery [MR/K026682/1]
- grant State of the Art Biomaterials Development and Characterization of the Cell-Biomaterial Interface from the MRC [MR/L012677/1]
- MRC [MR/L012677/1] Funding Source: UKRI
All vertebrates possess mechanisms to restore damaged tissues with outcomes ranging from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most often culminates in scar formation. Accounting for nearly 45% of deaths in the developed world, fibrosis is a process that stands diametrically opposed to functional tissue regeneration. Strategies to improve wound healing outcomes therefore require methods to limit fibrosis. Wound healing is guided by precise spatiotemporal deposition and remodelling of the extracellular matrix (ECM). The ECM, comprising the non-cellular component of tissues, is a signalling depot that is differentially regulated in scarring and regenerative healing. This Review focuses on the importance of the native matrix components during mammalian wound healing alongside a comparison to scar-free healing and then presents an overview of matrix-based strategies that attempt to exploit the role of the ECM to improve wound healing outcomes. (C) 2018 Elsevier B.V. All rights reserved.
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