期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 132, 期 -, 页码 33-56出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2018.06.020
关键词
Biomaterials; Dimension; Self-renewal; Differentiation; Reprogramming; Dedifferentiation; Transdifferentiation
资金
- National Natural Science Foundation of China [31670997, 51604104]
- Natural Science Foundation of Hunan Province [2015JJ1007, 2017JJ3421]
- Basic Research Program of Shenzhen City [JCYJ20160530193417959]
- Fundamental Research Funds for Central Universities [022800531107051107]
The interaction of biological cells with artificial biomaterials is one of the most important issues in tissue engineering and regenerative medicine. The interaction is strongly governed by physical and chemical properties of the materials and displayed with differentiated cellular behaviors, including cell self-renewal, differentiation, reprogramming, dedifferentiation, or transdifferentiation as a result. A number of engineered biomaterials with micro- or nano-structures have been developed to mimic structural components of cell niche and specific function of extra cellular matrix (ECM) over past two decades. In this review article, we briefly introduce the fabrication of biomaterials and their classification into zero-dimensional (OD), one-dimensional (1D), two-dimensional (2D) and three-dimensional (3D) ones. More importantly, the influence of different biomaterials on inducing cell self-renewal, differentiation, reprogramming, dedifferentiation, and transdifferentiation was discussed based on the progress at OD, 1D, 2D and 3D levels, following which the current research limitations and research perspectives were provided. (C) 2018 Elsevier B.V. All rights reserved.
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