相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。5-Aminolevulinic acid combined with sodium ferrous citrate ameliorates H2O2-induced cardiomyocyte hypertrophy via activation of the MAPK/Nrf2/HO-1 pathway
Mingyi Zhao et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2015)
Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation
Maria Armila Ruiz et al.
EPIGENETICS (2015)
Role of the Keap1/Nrf2 pathway in neurodegenerative diseases
Hiromi Yamazaki et al.
PATHOLOGY INTERNATIONAL (2015)
The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes
Elango Bhakkiyalakshmi et al.
PHARMACOLOGICAL RESEARCH (2015)
BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells
Walid T. Khaled et al.
NATURE COMMUNICATIONS (2015)
Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review
Amma Owusu-Ansah et al.
FRONTIERS OF MEDICINE (2015)
Regulation of Nrf2-an update
Suryakant K. Niture et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Targeted Fetal Hemoglobin Induction for Treatment of Beta Hemoglobinopathies
Susan P. Perrine et al.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2014)
The Effect and Side Effect of Hydroxyurea Therapy on Patients With beta-Thalassemia: A Systematic Review to December 2012
Mehrnoush Kosaryan et al.
HEMOGLOBIN (2014)
Proteasome Inhibition Induces Both Antioxidant and Hb F Responses in Sickle Cell Disease Via the Nrf2 Pathway
Vinod Pullarkat et al.
HEMOGLOBIN (2014)
Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes
Ji Hye Yang et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)
Monomethylfumarate Induces γ-Globin Expression and Fetal Hemoglobin Production in Cultured Human Retinal Pigment Epithelial (RPE) and Erythroid Cells, and in Intact Retina
Wanwisa Promsote et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2014)
A reduced curcuminoid analog as a novel inducer of fetal hemoglobin
Nattawara Chaneiam et al.
ANNALS OF HEMATOLOGY (2013)
Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells
Elizabeth R. Macari et al.
BLOOD (2013)
A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia
Suthat Fucharoen et al.
BRITISH JOURNAL OF HAEMATOLOGY (2013)
Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy
Alexander J. Gill et al.
CRITICAL REVIEWS IN IMMUNOLOGY (2013)
New Insights into the Pathogenesis of Preeclampsia The Role of Nrf2 Activators and their Potential Therapeutic Impact
N. Kweider et al.
GEBURTSHILFE UND FRAUENHEILKUNDE (2013)
Disruption of the Hbs1l-Myb Locus Causes Hereditary Persistence of Fetal Hemoglobin in a Mouse Model
Mikiko Suzuki et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction
Lihong Shi et al.
NATURE MEDICINE (2013)
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
S. Chowdhry et al.
ONCOGENE (2013)
Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury
Wenpeng Cui et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)
Regulation of Gγ-Globin Gene by ATF2 and Its Associated Proteins through the cAMP-Response Element
Li Liu et al.
PLOS ONE (2013)
Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells
Roberta Foresti et al.
PHARMACOLOGICAL RESEARCH (2013)
An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level
Daniel E. Bauer et al.
SCIENCE (2013)
Parallel Assessment of Globin Lentiviral Transfer in Induced Pluripotent Stem Cells and Adult Hematopoietic Stem Cells Derived from the Same Transplanted β-Thalassemia Patient
Alisa Tubsuwan et al.
STEM CELLS (2013)
The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis
S. Sampurno et al.
CELL DEATH & DISEASE (2013)
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
Emilia Kansanen et al.
REDOX BIOLOGY (2013)
Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine
Donald Lavelle et al.
BLOOD (2012)
Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3
Ana I. Rojo et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
Kai Takaya et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults
Alice E. Gallienne et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2012)
Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis
Patricia Rada et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks
Yosuke Hirotsu et al.
NUCLEIC ACIDS RESEARCH (2012)
Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice
Flavia C. Costa et al.
PLOS GENETICS (2012)
Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling
P. Palsamy et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)
Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice
Steffen E. Meiler et al.
BLOOD (2011)
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
Elizabeth R. Macari et al.
BLOOD (2011)
The multifunctional role of EKLF/KLF1 during erythropoiesis
Miroslawa Siatecka et al.
BLOOD (2011)
Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway
Valya Ramakrishnan et al.
BLOOD CELLS MOLECULES AND DISEASES (2011)
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
Ralf A. Linker et al.
BRAIN (2011)
Kruppel-like Factor 4 activates HBG gene expression in primary erythroid cells
Inderdeep S. Kalra et al.
BRITISH JOURNAL OF HAEMATOLOGY (2011)
Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic β-Type Globin Promoters in Differentiated Adult Erythroid Cells
Shuaiying Cui et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)
Winfred C. Wang et al.
LANCET (2011)
The Keap1-Nrf2 system as an in vivo sensor for electrophiles
Akira Uruno et al.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2011)
MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13
Vijay G. Sankaran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5′ olfactory receptor gene cluster
Nadia Solovieff et al.
BLOOD (2010)
Fetal globin expression is regulated by Friend of Prmt1
Thamar Bryn van Dijk et al.
BLOOD (2010)
c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression
Elisa Bianchi et al.
BLOOD (2010)
microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease
Carolyn Sangokoya et al.
BLOOD (2010)
cJun modulates Gγ-globin gene expression via an upstream cAMP response element
Sirisha Kodeboyina et al.
BLOOD CELLS MOLECULES AND DISEASES (2010)
Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line
Sima Zein et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2010)
Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6
Jian Xu et al.
GENES & DEVELOPMENT (2010)
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin
Joseph Borg et al.
NATURE GENETICS (2010)
KLF1 regulates BCL11A expression and γ- to β-globin gene switching
Dewang Zhou et al.
NATURE GENETICS (2010)
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
Toshihiko Ogura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Oxidative Stress and Oxidative Damage in Carcinogenesis
James E. Klaunig et al.
TOXICOLOGIC PATHOLOGY (2010)
Mir-144 selectively regulates embryonic α-hemoglobin synthesis during primitive erythropoiesis
Yan-Fang Fu et al.
BLOOD (2009)
Hydroxyurea Generates Nitric Oxide in Human Erythroid Cells: Mechanisms for γ-Globin Gene Activation
Tzu-Fang Lou et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2009)
Role of STAT3 and GATA-1 interactions in γ-globin gene expression
Xiao Yao et al.
EXPERIMENTAL HEMATOLOGY (2009)
Erythropoiesis: Model Systems, Molecular Regulators, and Developmental Programs
Asterios S. Tsiftsoglou et al.
IUBMB LIFE (2009)
The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells
Bart Baan et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)
Erythropoietin enhancement of rat pancreatic tumor cell proliferation requires the activation of ERK and JNK signals
Chhanda Bose et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)
Prospective Type 1 and Type 2 Disulfides of Keap1 Protein
Ryan Holland et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2008)
Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34(+) cells
Laure A. Moutouh-de Parseval et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and Amelioration of the phenotype of β-thalassemia
Manuela Uda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Effects of p38 MAP Kinase Inhibitors on the Differentiation and Maturation of Erythroid Progenitors
Deidre A. Dalmas et al.
TOXICOLOGIC PATHOLOGY (2008)
Different electrostatic Potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
Kit I. Tong et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Oral decitabine reactivates expression of the methylated γ-globin gene in Papio anubis
Donald Lavelle et al.
AMERICAN JOURNAL OF HEMATOLOGY (2007)
Thalidomide induces γ-globin gene expression through increased reactive oxygen species-mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis
Wulin Aerbajinai et al.
BLOOD (2007)
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
Stephan Menzel et al.
NATURE GENETICS (2007)
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait focus on chromosome 6q23 influencing fetal hemoglobin levels in adults
Swee Lay Thein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells
Subbiah Pugazhenthi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves γ-globin activation by CREB1 and ATF-2
Jose Sangerman et al.
BLOOD (2006)
Role of cyclic nucleotides in fetal hemoglobin induction in cultured CD34+ cells
Jeffrey R. Keefer et al.
EXPERIMENTAL HEMATOLOGY (2006)
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a Tethering mechanism - A two-site interaction model for the Nrf2-Keap1 complex
Michael McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces Phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver
P Perocco et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2006)
Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen species
CH Hsiao et al.
EXPERIMENTAL HEMATOLOGY (2006)
Sox6 directly silences epsilon globin expression in definitive erythropoiesis
Zanhua Yi et al.
PLOS GENETICS (2006)
The hydroxyurea-induced small GTP-binding protein SAR modulates γ-globin gene expression in human erythroid cells
DC Tang et al.
BLOOD (2005)
Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor
MO Arcasoy et al.
BRITISH JOURNAL OF HAEMATOLOGY (2005)
Role of c-Kit and erythropoietin receptor in erythropoiesis
V Munugalavadla et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2005)
Butyrate increases the efficiency of translation of γ-globin mRNA
RS Weinberg et al.
BLOOD (2005)
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway
H Motohashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A gene atlas of the mouse and human protein-encoding transcriptomes
AI Su et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The biochemistry of nitric oxide, nitrite, and hemoglobin: Role in blood flow regulation
MT Gladwin et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Negative regulation of γ-globin gene expression by cyclic AMP-dependent pathway in erythroid cells
A Inoue et al.
EXPERIMENTAL HEMATOLOGY (2004)
Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells
S Uddin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
A Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
YJ Shi et al.
CELL (2004)
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway
J Haynes et al.
BLOOD (2004)
The pathogenetic role of oncogenes deregulated by chromosomal translocation in B-cell malignancies
MJS Dyer
INTERNATIONAL JOURNAL OF HEMATOLOGY (2003)
Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin
O Witt et al.
BLOOD (2003)
p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors
BS Pace et al.
EXPERIMENTAL HEMATOLOGY (2003)
Effects of 5-aza-2 '-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease
Y Saunthararajah et al.
BLOOD (2003)
Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo
BS Pace et al.
BLOOD (2002)
Looping and interaction between hypersensitive sites in the active β-globin locus
B Tolhuis et al.
MOLECULAR CELL (2002)
Long-range chromatin regulatory interactions in vivo
D Carter et al.
NATURE GENETICS (2002)
An embryonic/fetal β-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer
O Tanabe et al.
EMBO JOURNAL (2002)
Stat3β inhibits γ-globin gene expression in erythroid cells
HA Foley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease
MT Gladwin et al.
BRITISH JOURNAL OF HAEMATOLOGY (2002)
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
Y Katoh et al.
GENES TO CELLS (2001)
Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation
MS Boosalis et al.
BLOOD (2001)
Potency of Michael reaction accepters as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen
LT Dinkova-Kostova et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
分享论文
