期刊
JOURNAL OF BIOMEDICAL SCIENCE
卷 23, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12929-016-0269-9
关键词
Zinc finger protein; Transcription factor; Cancer progression
资金
- Taiwan Ministry of Science [104-2627-B-006-001]
- Aim for the Top University Project [D105-35A07]
- Taiwan Ministry of Health and Welfare grant [105-TDU-B-211-124-003]
Zinc finger proteins are the largest transcription factor family in human genome. The diverse combinations and functions of zinc finger motifs make zinc finger proteins versatile in biological processes, including development, differentiation, metabolism and autophagy. Over the last few decades, increasing evidence reveals the potential roles of zinc finger proteins in cancer progression. However, the underlying mechanisms of zinc finger proteins in cancer progression vary in different cancer types and even in the same cancer type under different types of stress. Here, we discuss general mechanisms of zinc finger proteins in transcription regulation and summarize recent studies on zinc finger proteins in cancer progression. In this review, we also emphasize the importance of further investigations in elucidating the underlying mechanisms of zinc finger proteins in cancer progression.
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