期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 102, 期 1, 页码 215-221出版社
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.114.103283
关键词
B vitamin; brain atrophy; homocysteine; mild cognitive impairment; omega-3
资金
- Charles Wolfson Charitable Trust
- Medical Research Council
- Norwegian Research Council
- Norman Collisson Foundation
- Alzheimer's Research UK
- Henry Smith Charity
- John Coates Charitable Trust
- Thames Valley Dementias and Neurodegenerative Diseases Research Network of the National Institute for Health Research
- Sidney and Elizabeth Corob Charitable Trust
- Meda AB/Recip AB
Background: Increased brain atrophy rates are common in older people with cognitive impairment, particularly in those who eventually convert to Alzheimer disease. Plasma concentrations of omega-3 (omega-3) fatty acids and homocysteine are associated with the development of brain atrophy and dementia. Objective: We investigated whether plasma omega-3 fatty acid concentrations (eicosapentaenoic acid and docosahexaenoic acid) modify the treatment effect of homocysteine-lowering B vitamins on brain atrophy rates in a placebo-controlled trial (VITACOG). Design: This retrospective analysis included 168 elderly people (>= 70 y) with mild cognitive impairment, randomly assigned either to placebo (n = 83) or to daily high-dose B vitamin supplementation (folic acid, 0.8 mg; vitamin B-6, 20 mg; vitamin B-12, 0.5 mg) (n = 85). The subjects underwent cranial magnetic resonance imaging scans at baseline and 2 y later. The effect of the intervention was analyzed according to tertiles of baseline omega-3 fatty acid concentrations. Results: There was a significant interaction (P = 0.024) between B vitamin treatment and plasma combined omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) on brain atrophy rates. In subjects with high baseline w-3 fatty acids (>590 mu mol/L), B vitamin treatment slowed the mean atrophy rate by 40.0% compared with placebo (P = 0.023). B vitamin treatment had no significant effect on the rate of atrophy among subjects with low baseline omega-3 fatty acids (<390 mu mol/L). High baseline omega-3 fatty acids were associated with a slower rate of brain atrophy in the B vitamin group but not in the placebo group. Conclusions: The beneficial effect of B vitamin treatment on brain atrophy was observed only in subjects with high plasma omega-3 fatty acids. It is also suggested that the beneficial effect of omega-3 fatty acids on brain atrophy may be confined to subjects with good B vitamin status. The results highlight the importance of identifying subgroups likely to benefit in clinical trials.
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