期刊
ACTA TROPICA
卷 178, 期 -, 页码 97-102出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.actatropica.2017.09.019
关键词
Lichen substances; Ramalina aspera; Schistosoma mansoni; Biomphalaria glabrata; Molluscicide activity
资金
- Brazilian Fostering Agency CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- State fostering agency FACEPE (Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- FACEPE
- CNPq
In this study, the molluscicidal and antiparasitic activities of divaricatic acid was evaluated, targeting the mollusc Biomphalaria glabrata and cercariae of the helminth Schistosoma mansoni. In addition, the environmental toxicity of divaricatic acid was assessed by bioassay using the microcrustacean Artemia salina. Divaricatic acid showed high toxicity against both adult snails (5 mu g/mL) and embryos (20 mu g/mL after 6 h of exposure). Similar activity was observed in Schistosoma mansoni cercariae after only a short exposure time (10 mu g/mL after 30 min of exposure). The divaricatic acid did not show toxicity in the acute test using Artemia sauna at concentrations equal to or below 200 mu g/mL. The divaricatic acid proved to be a promising substance for the elimination of the snail Biomphalaria glabrata, an intermediate host of schistosomiasis, as well as the cercariae of the pathogen, while being non-toxic to the Anemia sauna at the same concentrations. This is the first experimental observation of the molluscicidal and cercaricide activity of divaricatic acid.
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