期刊
EXPERIMENTAL AND MOLECULAR PATHOLOGY
卷 99, 期 3, 页码 596-610出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yexmp.2015.09.001
关键词
Alcoholic liver disease; Alcohol dehydrogenase; Betaine; CYP2E1; Hepatocarcinogenesis; Liver fibrosis; Hepatitis B and C viral infection; Human immunodeficiency virus; Liver transplant
类别
资金
- European Association for the Biological Research on Alcoholism (ESBRA)
- In Vitro Drug Safety and Biotechnology
- Mahaffy Innovative Grant, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
- [5U01AA-021818-03]
The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical research, translational research, pathogenesis and therapies. A special accent is placed on alcohol misuse, as alcohol is a legally commercialized and taxable product. Drinking alcohol, particularly from a young age, is a major health problem. Alcoholism is known to contribute to morbidity and mortality. A systematic literature search was performed in order to obtain updated data (2008-2015). The review is focused on genetic polymorphisms of alcohol metabolizing enzymes and the role of cytochrome p450 2E1 and iron in ALD. Alcohol-mediated hepatocarcinogenesis is also discussed in the presence or absence of co-morbidities such as viral hepatitis C as well as therapeutic the role of innate immunity in ALD-HCV. Moreover, emphasis was placed on alcohol and drug interactions, as well as liver transplantation for end-stage ALD. Finally, the time came to eradicate alcohol-induced liver and intestinal damage by using betaine. (C) 2015 Elsevier Inc. All rights reserved.
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