期刊
ACTA PHARMACOLOGICA SINICA
卷 39, 期 5, 页码 802-824出版社
NATURE PUBL GROUP
DOI: 10.1038/aps.2017.193
关键词
Salvia miltiorrhiza Burge; Danshen; cardiovascular diseases; herbal medicine; traditional Chinese medicine
资金
- National Natural Science Foundation of China [81473205, 81400359, 81673433]
- National Engineering and Technology Research Center for New drug Druggability Evaluation (Seed Program of Guangdong Province)
- Major Project of Guangdong Provincial Department of Science and Technology [2015B020232009, 2014B020210003, 2013B090700010]
- Major Project of Platform Construction Education Department of Guangdong Province [2014GKPT002]
- Guangdong Province Science and Technology Plan project-Public Research and Capacity Construction [3]
- Guangzhou Science and Technology Projects [201604020121, 201509030006]
- Guangdong Provincial Engineering Laboratory of Druggability and New Drugs Evaluation
- Guangzhou Key Laboratory of Druggability Assessment for Biologically Active Compounds
- 111 Project of China [B16047]
Salvia miltiorrhiza Burge (Danshen) is an eminent medicinal herb that possesses broad cardiovascular and cerebrovascular protective actions and has been used in Asian countries for many centuries. Accumulating evidence suggests that Danshen and its components prevent vascular diseases, in particular, atherosclerosis and cardiac diseases, including myocardial infarction, myocardial ischemia/reperfusion injury, arrhythmia, cardiac hypertrophy and cardiac fibrosis. The published literature indicates that lipophilic constituents (tanshinone I, tanshinone IIa, tanshinone IIb, cryptotanshinone, dihydrotanshinone, etc) as well as hydrophilic constituents (danshensu, salvianolic acid A and B, protocatechuic aldehyde, etc) contribute to the cardiovascular protective actions of Danshen, suggesting a potential synergism among these constituents. Herein, we provide a systematic up-to-date review on the cardiovascular actions and therapeutic potential of major pharmacologically active constituents of Danshen. These bioactive compounds will serve as excellent drug candidates in small-molecule cardiovascular drug discovery. This article also provides a scientific rationale for understanding the traditional use of Danshen in cardiovascular therapeutics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据