期刊
ACTA PAEDIATRICA
卷 107, 期 4, 页码 577-580出版社
WILEY
DOI: 10.1111/apa.14217
关键词
Biologics; Children; Cryopyrin-associated periodic syndrome; Interleukin-1; Periodic fever
类别
Cryopyrin-associated periodic syndrome (CAPS) is caused by a mutation in the NLRP3 gene encoding cryopyrin production. Overproduction of interleukin-1 (IL-1) leads to symptoms that are associated with elevated inflammatory markers, including periodic fever and a rash. We provide a clinical overview of CAPS in children, including three Finnish case studies. Conclusion: When CAPS has been diagnosed, an IL-1 blockade with biological should be introduced to lessen the symptoms and to prevent the progression of organ damage.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据