相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6
Kaichuan Zhu et al.
BIOLOGICAL PSYCHIATRY (2018)
BACE inhibition-dependent repair of Alzheimer's pathophysiology
Aylin D. Keskin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
High plasticity of axonal pathology in Alzheimer's disease mouse models
Lidia Blazquez-Llorca et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2017)
Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease
Katherine R. Sadleir et al.
ACTA NEUROPATHOLOGICA (2016)
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients
Matthew E. Kennedy et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury
Marc Suarez-Calvet et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions
Severin Filser et al.
BIOLOGICAL PSYCHIATRY (2015)
Beneficial Effects of the β-Secretase Inhibitor GRL-8234 in 5XFAD Alzheimer's Transgenic Mice Lessen During Disease Progression
Latha Devi et al.
CURRENT ALZHEIMER RESEARCH (2015)
Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice
Deepak R. Thakker et al.
JOURNAL OF NEUROSCIENCE (2015)
The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans
Patrick C. May et al.
JOURNAL OF NEUROSCIENCE (2015)
Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
Katherine R. Sadleir et al.
MOLECULAR NEURODEGENERATION (2015)
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice
Ulf Neumann et al.
MOLECULAR NEURODEGENERATION (2015)
EFFECTS OF BACE1 HAPLOINSUFFICIENCY ON APP PROCESSING AND Aβ CONCENTRATIONS IN MALE AND FEMALE 5XFAD ALZHEIMER MICE AT DIFFERENT DISEASE STAGES
L. Devi et al.
NEUROSCIENCE (2015)
Lessons from a BACE1 inhibitor trial: Off-site but not off base
Debomoy K. Lahiri et al.
ALZHEIMERS & DEMENTIA (2014)
Lessons from a Failed γ-Secretase Alzheimer Trial
Bart De Strooper
CELL (2014)
Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APPLondon Mice
Helmut Jacobsen et al.
JOURNAL OF NEUROSCIENCE (2014)
In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques
Steffen Burgold et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)
Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease
Joanna F. McCarter et al.
ACTA NEUROPATHOLOGICA (2013)
The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
Patty C. Kandalepas et al.
ACTA NEUROPATHOLOGICA (2013)
Elevated Aβ42 in Aged, Non-demented Individuals with Cerebral Atherosclerosis
Katherine Sadleir et al.
Current Alzheimer Research (2013)
Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles
Cyril Cheret et al.
EMBO JOURNAL (2013)
Increased Expression of Reticulon 3 in Neurons Leads to Reduced Axonal Transport of β Site Amyloid Precursor Protein-cleaving Enzyme 1
Minzi Deng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
Victor L. Villemagne et al.
LANCET NEUROLOGY (2013)
Amyloid plaque formation precedes dendritic spine loss
Tobias Bittner et al.
ACTA NEUROPATHOLOGICA (2012)
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
Peer-Hendrik Kuhn et al.
EMBO JOURNAL (2012)
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
Thorlakur Jonsson et al.
NATURE (2012)
Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
Randall J. Bateman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Fluid Biomarkers in Alzheimer Disease
Kaj Blennow et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
The membrane-bound aspartyl protease BACE1: molecular and functional properties in Alzheimer's disease and beyond
Bastian Dislich et al.
FRONTIERS IN PHYSIOLOGY (2012)
In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks
Steffen Burgold et al.
ACTA NEUROPATHOLOGICA (2011)
β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice
Wan-Pin Chang et al.
FASEB JOURNAL (2011)
In Vivo Imaging of Intersynaptic Vesicle Exchange Using VGLUT1Venus Knock-In Mice
Etienne Herzog et al.
JOURNAL OF NEUROSCIENCE (2011)
Long-Term In Vivo Imaging of β-Amyloid Plaque Appearance and Growth in a Mouse Model of Cerebral β-Amyloidosis
Jasmin K. Hefendehl et al.
JOURNAL OF NEUROSCIENCE (2011)
Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor
Patrick C. May et al.
JOURNAL OF NEUROSCIENCE (2011)
Amyloid beta-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process
Erik Hellstrand et al.
ACS CHEMICAL NEUROSCIENCE (2010)
β-Secretase Inhibitor Potency Is Decreased by Aberrant β-Cleavage Location of the Swedish Mutant Amyloid Precursor Protein
Hidekuni Yamakawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates Aβ Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease
Hiroaki Fukumoto et al.
JOURNAL OF NEUROSCIENCE (2010)
Classification and basic pathology of Alzheimer disease
Charles Duyckaerts et al.
ACTA NEUROPATHOLOGICA (2009)
Widespread Changes in Dendritic Spines in a Model of Alzheimer's Disease
S. Knafo et al.
CEREBRAL CORTEX (2009)
beta-Secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development
Xue-Mei Zhang et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2009)
Molecular insights into β-galactoside α2,6-sialyltransferase secretion in vivo
Shinobu Kitazume et al.
GLYCOBIOLOGY (2009)
γ-Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway
Tobias Bittner et al.
JOURNAL OF NEUROSCIENCE (2009)
Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice
Ping Yan et al.
JOURNAL OF NEUROSCIENCE (2009)
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
Anthony Holtmaat et al.
NATURE PROTOCOLS (2009)
Worldwide variation in the doubling time of Alzheimer's disease incidence rates
Kathryn Ziegler-Graham et al.
ALZHEIMERS & DEMENTIA (2008)
γ-secretase inhibition and modulation for Alzheimer's disease
Michael S. Wolfe
CURRENT ALZHEIMER RESEARCH (2008)
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice
Lisa McConlogue et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Expression of APP pathway mRNAs and proteins in Alzheimer's disease
Toshifumi Matsui et al.
BRAIN RESEARCH (2007)
Dendritic pathology in prion disease starts at the synaptic spine
Martin Fuhrmann et al.
JOURNAL OF NEUROSCIENCE (2007)
β-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques:: Implications for Alzheimer's disease pathogenesis
Jie Zhao et al.
JOURNAL OF NEUROSCIENCE (2007)
Spatial relationship between synapse loss and β-amyloid deposition in Tg2576 mice
Hongxin Dong et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2007)
Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Rebecca Radde et al.
EMBO REPORTS (2006)
Persistent amyloidosis following suppression of Aβ production in a transgenic model of Alzheimer disease
JL Jankowsky et al.
PLOS MEDICINE (2005)
Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice
S Boncristiano et al.
NEUROBIOLOGY OF AGING (2005)
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients
R Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Take five -: BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation
C Haass
EMBO JOURNAL (2004)
β-secretase activity increases with aging in human, monkey, and mouse brain
H Fukumoto et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Intramembrane proteotysis: Theme and variations
MS Wolfe et al.
SCIENCE (2004)
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
J Tsai et al.
NATURE NEUROSCIENCE (2004)
Aph-1, Pen-2, and nicastrin with presenilin generate an active γ-secretase complex
B De Strooper
NEURON (2003)
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
LB Yang et al.
NATURE MEDICINE (2003)
Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
WE Klunk et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)
β-secretase protein and activity are increased in the neocortex in Alzheimer disease
H Fukumoto et al.
ARCHIVES OF NEUROLOGY (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
DR Thal et al.
NEUROLOGY (2002)
Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment
DL King et al.
BRAIN RESEARCH (2002)
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
Y Luo et al.
NATURE NEUROSCIENCE (2001)
分享论文
