4.4 Article

Clinical response to Vim's thalamic stereotactic radiosurgery for essential tremor is associated with distinctive functional connectivity patterns

期刊

ACTA NEUROCHIRURGICA
卷 160, 期 3, 页码 611-624

出版社

SPRINGER WIEN
DOI: 10.1007/s00701-017-3456-x

关键词

Resting-state; fMRI; Essential tremor; Ventro-intermediate nucleus; Radiosurgery; Independent component analysis; Thalamotomy

资金

  1. Swiss National Science Foundation [SNSF-205321-157040]
  2. Centre d'Imagerie BioMedicale (CIBM) of the University of Lausanne (UNIL)
  3. Swiss Federal Institute of Technology Lausanne (EPFL)
  4. University of Geneva (UniGe)
  5. Centre Hospitalier Universitaire Vaudois (CHUV)
  6. CHU Timone, Marseille, France
  7. Hopitaux Universitaires de Geneve (HUG)
  8. Leenaards Foundation
  9. Jeantet Foundation

向作者/读者索取更多资源

Essential tremor (ET) is the most common movement disorder. Drug-resistant ET can benefit from standard surgical stereotactic procedures (deep brain stimulation, thalamotomy) or minimally invasive high-intensity focused ultrasound (HIFU) or stereotactic radiosurgical thalamotomy (SRS-T). Resting-state fMRI (rs-fMRI) is a non-invasive imaging method acquired in absence of a task. We examined whether rs-fMRI correlates with tremor score on the treated hand (TSTH) improvement 1 year after SRS-T. We included 17 consecutive patients treated with left unilateral SRS-T in Marseille, France. Tremor score evaluation and rs-fMRI were acquired at baseline and 1 year after SRS-T. Resting-state data (34 scans) were analyzed without a priori hypothesis, in Lausanne, Switzerland. Based on degree of improvement in TSTH, to consider SRS-T at least as effective as medication, we separated two groups: 1, <= 50% (n = 6, 35.3%); 2, > 50% (n = 11, 64.7%). They did not differ statistically by age (p = 0.86), duration of symptoms (p = 0.41), or lesion volume at 1 year (p = 0.06). We report TSTH improvement correlated with interconnectivity strength between salience network with the left claustrum and putamen, as well as between bilateral motor cortices, frontal eye fields and left cerebellum lobule VI with right visual association area (the former also with lesion volume). Longitudinal changes showed additional associations in interconnectivity strength between right dorsal attention network with ventro-lateral prefrontal cortex and a reminiscent salience network with fusiform gyrus. Brain connectivity measured by resting-state fMRI relates to clinical response after SRS-T. Relevant networks are visual, motor, and attention. Interconnectivity between visual and motor areas is a novel finding, revealing implication in movement sensory guidance.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据