期刊
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
卷 65, 期 3, 页码 317-323出版社
AKADEMIAI KIADO ZRT
DOI: 10.1556/030.65.2018.024
关键词
B. fragilis; carbapenem resistance; ertapenem; imipenem; IS1187
资金
- ESCMID Study Group on Anaerobic Infections (ESGAI)
An imipenem-resistant Bacteroides fragilis strain was isolated from the blood of a 72-year-old male patient with a urinary bladder tumor in Osijek, Croatia. This strain was also resistant to ampicillin, piperacillin/tazobactam, cefoxitin, clindamycin, tetracycline, and harbored cfiA, ermF, and tetQ genes where the high-level expression of the cfiA carbapenem-resistant gene was driven by an IS//87 element. Interestingly, despite the carbapenem-resistant feature of the B. fragilis from blood, the patient relatively easily recovered from the bacteremia. It was the first characterized imipenem-resistant B. fragilis isolate with its case report from Croatia, which confirmed the appearance of carbapenem-resistant B. fragilis strains, that continues worldwide with low incidence and the molecular characteristics vary temporally and geographically.
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