期刊
ACTA DERMATO-VENEREOLOGICA
卷 98, 期 2, 页码 173-179出版社
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-2774
关键词
itch; pruritus; chronic scratch lesions; prurigo nodularis; Hyde's prurigo; interleukin-31; neurokinin-1
类别
资金
- German Federal Ministry of Education and Research (BMBF) [01KG1305]
- European Academy for Dermatology and Venereology (EADV) [2016-012]
- Galderma International
Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules. PN evolves along with chronic pruritus in the context of diverse dermatological, systemic, neurological or psychiatric conditions. Permanent scratching is possibly a major trigger of PN, although its exact pathophysiology remains unclear. Current state-of-the-art therapy for PN consists of topical steroids, capsaicin, calcineurin inhibitors, ultraviolet (UV) therapy, systemic administration of gabapentinoids, mu-opioid receptor antagonists, antidepressants or immunosuppressants. Novel treatment concepts, such as inhibitors of neurokinin-1, opioid and interleukin-31 receptors, have been developed and are currently being clinically tested.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据