期刊
ACTA DERMATO-VENEREOLOGICA
卷 98, 期 6, 页码 576-584出版社
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-2905
关键词
psoriasis; PUVA; UVB; imiquimod; interleukin-9; senescence
类别
资金
- Austrian Science Fund FWF [W1241]
- Medical University of Graz through the PhD programme DK-MOLIN
The effects of 8-Methoxypsoralen plus ultraviolet A (PUVA) or ultraviolet B (UVB) alone on imiquimodinduced psoriasis were examined in a mouse model. Mouse skin was treated with repetitive sub-phototoxic doses of PUVA or UVB before or during the induction of toll-like receptor 7/8 activation and psoriasis through the application of imiquimod. PUVA, to a greater degree than UVB, suppressed the established imiquimod-induced psoriatic phenotype, but pretreatment with PUVA prior to administration of imiquimod also reduced the susceptibility of murine skin to respond to imiquimod to a greater degree than did pretreatment with UVB. PUVA downregulated baseline levels of miRNA27a and 29a, as well as interferon-., interleukin-17 and -9, cytokines, which drive psoriatic inflammation. Microarray analysis showed enrichment of senescence pathway genes linked to upregulation of p16/p21 proteins after PUVA pretreatment. However, the anti-psoriatic effect of PUVA was lost when there was an interval of 7 days between final exposure to PUVA and the start of administration of imiquimod. This indicated that (UVB and) PUVA diminished imiquimodinduced established psoriatic inflammation, but also primed the skin in favour of a reduced responsiveness to toll-like receptor activation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据