期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 103, 期 1, 页码 161-167出版社
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.115.118588
关键词
nutrition; ovarian cancer; saturated fat; serous; prospective cohort; diet
资金
- European Commission [Directorate-General for Health and Consumers (DG-SANCO)]
- International Agency for Research on Cancer
- Dutch Cancer Society
- World Cancer Research Fund
- NIH [K99 ES023504]
- PhRMA Foundation
- Danish Cancer Society (Denmark)
- Ligue Contre le Cancer (France)
- Institut Gustave Roussy (France)
- Mutuelle Generale de l'Education Nationale (France)
- Institut National de la Sante et de la Recherche Medicale (Inserm) (France)
- Deutsche Krebshilfe (Germany)
- Deutsches Krebsforschungszentrum (Germany)
- Federal Ministry of Education and Research (Germany)
- Hellenic Health Foundation (Greece)
- Associazione Italiana per la Ricerca sul Cancro (AIRC) Italy
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare and Sports (VWS) (Netherlands)
- Netherlands Cancer Registry (NKR) (Netherlands)
- LK Research Funds (Netherlands)
- Dutch Prevention Funds (Netherlands)
- Dutch ZON (Zorg Onderzoek Nederland) (Netherlands)
- World Cancer Research Fund (Netherlands)
- Statistics Netherlands (Netherlands)
- Health Research Fund [Fund for Health of Spain (FIS)] (Spain)
- Regional Government of Andalucia (Spain)
- Regional Government of Asturias (Spain)
- Regional Government of Basque Country (Spain)
- Regional Government of Murcia (Spain) [6236]
- Regional Government of Navarra (Spain)
- Instituto de Salud Carlos III (ISCIII) Redes Tematicas de Investigacion Cooperativa (RETIC) (Spain) [RD06/0020]
- Swedish Cancer Society (Sweden)
- Swedish Research Council (Sweden)
- County Council of Skane (Sweden)
- County Council of Vasterbotten (Sweden)
- Cancer Research UK (United Kingdom) [14136, C570/A16491, C8221/A19170]
- Medical Research Council (United Kingdom) [1000143, MR/M012190/1]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R21ES025052, K99ES023504, R00ES023504] Funding Source: NIH RePORTER
- Cancer Research UK [14136, 16491] Funding Source: researchfish
- Medical Research Council [MC_U106179471, MC_UU_12015/1, G1000143, G0401527] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10114, NF-SI-0512-10135] Funding Source: researchfish
- MRC [MC_UU_12015/1] Funding Source: UKRI
Background: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk. Objective: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort. Design: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs. Results: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall BR: 1.21; 95% CI: 1.04, 1.41). Conclusion: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.
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