期刊
ACTA BIOMATERIALIA
卷 71, 期 -, 页码 279-292出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2018.03.011
关键词
Supramolecular bioelastomer; Urethane-based PEGylated PGS; Low-temperature curing; Highly-customized; Multiple biomedical applications
资金
- National Natural Science Foundation of China for Innovative Research Groups [51621002]
- National Natural Science Foundation of China [31330028, 31470924]
- 111 Project [B14018]
- Fundamental Research Funds for the Central Universities [222201718002]
Poly (glycerol sebacate) (PGS), a tough elastomer, has been widely explored in tissue engineering due to the desirable mechanical properties and biocompatibility. However, the complex curing procedure (high temperature and vacuum) and limited hydrophilicity (similar to 90 degrees of wetting angle) greatly impede its functionalities. To address these challenges, a urethane-based low-temperature setting, PEGylated PGS bioelastomer was developed with and without solvent. By simultaneously tailoring PEG and hexamethylene diisocyanate (HDI) contents, the elastomers X-P-mUs (X referred to the PEG content and m referred to HDI content) with a broad ranging mechanical properties and customized hydrophilicity were constructed. The X-P-mUs synthesized exhibited adjustable tensile Young's modulus, ultimate tensile strength and elongation at break in the range of 1.0 MPa-14.2 MPa, 0.3 MPa-7.6 MPa and 53.6%-272.8%, with the water contact angle varying from 28.6 degrees to 71.5 degrees, respectively. Accordingly, these elastomers showed favorable biocompatibility in vitro and mild host response in vivo. Furthermore, the potential applications of X-P-mU elastomers prepared with solvent-base and solvent-free techniques in biomedical fields were investigated. The results showed that these X-P-mU elastomers with high molding capacity at mild temperature could be easily fabricated into various shapes, used as reinforcement for fragile materials, and controllable delivery of drugs and proteins with excellent bioactivity, demonstrating that the X-P-mU elastomers could be tailored as potential building blocks for diverse applications in biomedical research. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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