期刊
ACTA BIOMATERIALIA
卷 71, 期 -, 页码 200-214出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2018.03.007
关键词
Zinc; Hydroxyapatite; Composite; Degradation; Biocompatibility
资金
- National Key Research and Development Program of China [2016YFC1102402]
- National Natural Science Foundation of China [51431002]
- NSFC/RGC Joint Research Scheme [51361165101, 5161101031]
- NSFC-RFBR Cooperation Project [51611130054]
Recent studies indicate that there is a great demand to optimize pure Zn with tunable degradation rates and more desirable biocompatibility as orthopedic implants. Metal matrix composite (MMC) can be a promising approach for this purpose. In this study, MMC with pure Zn as a matrix and hydroxyapatite (HA) as reinforcements were prepared by spark plasma sintering (SPS). Feasibility of novel Zn-HA composites to be used as orthopedic implant applications was systematically evaluated. After sintering, HA distributed in the Zn particle boundaries uniformly. Corrosion tests indicated that the degradation rates of Zn-HA composites were adjustable due to the biphasic effects of HA. Zn-HA composites showed significantly improved cell viability of osteoblastic MC3T3-E1 cells compared with pure Zn. Both pure Zn and composites exhibited a low thrombosis risk and hemolysis rates while a Zn ion concentration-dependent effect was found on coagulation time. An effective antibacterial property was observed as well. The volume loss of pure Zn and Zn-5HA composite was 1.7% and 3.2% after 8 weeks' implantation. Histological analysis found newly formed bone surrounding pure Zn and Zn-5HA composite at week 4 and increased bone mass over time. With prolonged implantation time, Zn-5HA composite was more effective on stimulating new bone formation than pure Zn. In summary, MMC is a feasible way to design Zn based materials with adjustable degradation rates and improved biocompatibility. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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