期刊
ACTA BIOMATERIALIA
卷 65, 期 -, 页码 450-461出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2017.11.009
关键词
3D scaffolds; Levofloxacin; pH-dependent release; Biofilm; S. aureus; Biocompatibility; Co-culture assays
资金
- European Research Council (Advanced Grant VERDI) [694160]
- Spanish MINECO [MAT2013-43299-R, MAT2015-64831-R, MAT2016-75611-R AEI/FEDER, UE]
Multifunctional-therapeutic three-dimensional (3D) scaffolds have been prepared. These biomaterials are able to destroy the S. aureus bacterial biofilm and to allow bone regeneration at the same time. The present study is focused on the design of pH sensitive 3D hierarchical meso-macroporous 3D scaffolds based on MGHA nanocomposite formed by a mesostructured glassy network with embedded hydroxyapatite nanoparticles, whose mesopores have been loaded with levofloxacin (Levo) as antibacterial agent. These 3D platforms exhibit controlled and pH-dependent Levo release, sustained over time at physiological pH (7.4) and notably increased at infection pH (6.7 and 5.5), which is due to the different interaction rate between diverse Levo species and the silica matrix. These 3D systems are able to inhibit the S. aureus growth and to destroy the bacterial biofilm without cytotoxic effects on human osteoblasts and allowing an adequate colonization and differentiation of preosteoblastic cells on their surface. These findings suggest promising applications of these hierarchical MGHA nanocomposite 3D scaffolds for the treatment and prevention of bone infection. (C) 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据