4.8 Article

Hollow mesoporous zirconia delivery system for biomineralization precursors

期刊

ACTA BIOMATERIALIA
卷 67, 期 -, 页码 366-377

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2017.11.049

关键词

Zirconia; Nanocapsules; Tissue engineering; Biomineralization; Osteoinduction

资金

  1. National Nature Science Foundation of China [81722015, 81500883, 81400555]
  2. National Key Research and Development Program of China [2016YFC1101400]
  3. Guangdong Public Research and Competence Special Fund Expenditure [2015A030401035]
  4. Ph.D. Programs Foundation of Ministry of Education of China [20130171120121]
  5. Young Elite Scientist Sponsorship Program by CAST [2015QNRC001]

向作者/读者索取更多资源

Strategies based on the combination of nanocarrier delivery systems and scaffolds provide bone tissue engineering scaffolds with multifunctional capability. Zirconia, a biocompatible ceramic commonly used in orthopedic and dental implants, was used to synthesize hollow mesoporous nanocapsules for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of amorphous calcium phosphate (PAH-ACP) for collagen biomineralization and bone marrow stromal cells osteoinduction. Hollow mesoporous zirconia (hmZrO(2)) nanocapsules loaded with biomimetic precursors exhibited pH-sensitive release capability and good biocompatibility. The PAH-ACP released from loaded hmZrO(2) still retained the ability to infiltrate and mineralize collagen fibrils as well as exhibited osteoinductivity. A collagen scaffold blended with PAH-ACP@hmZrO(2) supplement and stem cells may be a promising tool for bone tissue engineering. Statement of Significance The advent of nanotechnology has catalyzed the development of bone tissue engineering strategies based on the combination of nanocarrier delivery systems and scaffolds, which provide distinct advantages, including the possibilities of sustained release and protection of the bioactive agents, site-specific pharmacological effects and reduction of side effects. Herein, hollow mesoporous zirconia (hmZrO(2)) nanocapsules with pH-sensitive capacity were synthesized for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of ACP (PAH-ACP). The loaded nanocapsules show good biocompatibility and demonstrate bioactivities for collagen biomineralization and bone marrow stromal cells osteoinduction. Our results may offer a promising tool for designing bone tissue engineering cock-tail therapy involving seeding scaffolds with biomineralization precursors loaded hmZrO(2) supplement and stem cells. (C) 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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