期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 102, 期 5, 页码 1081-1087出版社
AMER SOC NUTRITION-ASN
DOI: 10.3945/ajcn.115.115295
关键词
pregnancy; supplementation; tracking; vitamin D; epidemiology; osteoporosis
资金
- Medical Research Council
- British Heart Foundation
- Arthritis Research UK
- National Institute for Health Research (NIHR) Southampton Biomedical Research Centre
- University of Southampton
- NIHR Musculoskeletal Biomedical Research Unit, University of Oxford
- European Union [289346, 613977]
- University Hospital Southampton National Health Service Foundation Trust
- British Heart Foundation [RG/07/009/23120] Funding Source: researchfish
- Medical Research Council [MC_UU_12011/1, U1475000002, MC_UP_A620_1014, MC_UP_A620_1017, MC_U147585819, MC_UP_A620_1015, U1475000001, MC_UU_12011/2, G0400491, MC_UU_12011/4, MC_U147585824, MC_U147585827] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10085, NF-SI-0508-10082, 10/33/04] Funding Source: researchfish
- Versus Arthritis [17702] Funding Source: researchfish
- MRC [MC_UU_12011/2, MC_UP_A620_1015, MC_UP_A620_1017, MC_UU_12011/4, G0400491, MC_U147585819, MC_U147585827] Funding Source: UKRI
Background: The role of maternal 25-hydroxyvitamin D [25(OH)D] in fetal development is uncertain, and findings of observational studies have been inconsistent. Most studies have assessed 25(OH)D only one time during pregnancy, but to our knowledge, the tracking of an individual's 25(OH)D during pregnancy has not been assessed previously. Objective: We determined the tracking of serum 25(OH)D from early to late pregnancy and factors that influence this. Design: The Southampton Women's Survey is a prospective mother-offspring birth-cohort study. Lifestyle, diet, and 25(OH)D status were assessed at 11 and 34 wk of gestation. A Fourier transformation was used to model the seasonal variation in 25(OH)D for early and late pregnancy separately, and the difference between the measured and seasonally modeled 25(OH)D was calculated to generate a season-corrected 25(OH)D. Tracking was assessed with the use of the Pearson correlation coefficient, and multivariate linear regression was used to determine factors associated with the change in season-corrected 25(OH)D. Results: A total of 1753 women had 25(OH)D measured in both early and late pregnancy. There was a moderate correlation between season-corrected 25(OH)D measurements at 11 and 34 wk of gestation (r = 0.53, P < 0.0001; n = 1753). Vitamin D supplementation was the strongest predictor of tracking; in comparison with women who never used supplements, the discontinuation of supplementation after 11 wk was associated with a reduction in season-corrected 25(OH)D (beta = -7.3 nmol/L; P < 0.001), whereas the commencement (beta = 12.6 nmol/L; P < 0.001) or continuation (beta = 6.6 nmol/L; P < 0.001) of supplementation was associated with increases in season-corrected 25(OH)D. Higher pregnancy weight gain was associated with a reduction in season-corrected 25(OH)D (beta = -0.4 nmol . L-1 . kg(-1); P = 0.015), whereas greater physical activity (beta = 0.4 nmol/L per h/wk; P = 0.011) was associated with increases. Conclusions: There is a moderate tracking of 25(OH)D status through pregnancy; factors such as vitamin D supplementation, weight gain, and physical activity are associated with changes in season-corrected 25(OH)D from early to late gestation. These findings have implications for study designs and analyses and approaches to intervention studies and clinical care.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据