期刊
ANNALS OF TRANSPLANTATION
卷 21, 期 -, 页码 -出版社
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/AOT.899340
关键词
Liver; Mild Cognitive Impairment; Transplantation Conditioning
Background: Because of the restricted data available on patients with postoperative cognitive dysfunction (POCD) in orthotopic liver transplantation (OLT), the goal of our study was to determine the outcome of dexmedetomidine (DEX) on POCD and the mechanism operating in OLT patients. Material/Methods: Our study included 80 patients randomly divided into 2 equal groups: the DEX group and the control group. In the DEX group, our patients received an initial dose of DEX at 1 mu g/kg for 10 min followed by a continuous infusion at 0.3 mu g/kg/h until the end of surgery. The control group received a saline treatment, and neurological tests were performed to assess the status of POCD. Serum level of beta-amyloid protein (A beta) and neuronal microtubule-associated protein (Tau) were measured at designated time points: at pre-operation (T-1), 0.5 h after the anhepatic phase (T-2), 2 h after the reperfusion of the new liver (T-3), at the completion of operation (T-4), at day 1 (T-5), and at day 7 (T-6) after the operation. Results: The incidence of POCD was significantly reduced in the DEX group (P = 0.017). The score from the neurological tests was significantly decreased in the control group after the operation, but no statistical difference was observed in the DEX group. The DEX groups demonstrated a lower level of b-amyloid and Tau protein than those at the corresponding time points (T-4 similar to T-6) in the control group (P < 0.01). Conclusions: Dexmedetomidine reduced the incidence of postoperative cognitive dysfunction in orthotopic liver transplantation patients. The decreased levels of b-amyloid and Tau protein may have contributed to this favorable outcome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据