期刊
ACS NANO
卷 12, 期 7, 页码 7292-7300出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b03500
关键词
nanoparticles; protein corona; blood-brain barrier; brain; biological barriers
类别
资金
- European Union's HORIZON 2020 Program for research, technological development, and demonstration [642028 H2020-MSCA-ITN-2014]
- Joint Programme-Neurodegenerative Disease Research (JPND Research 2015) [CUP B42F160000900008]
Engineered nanoparticles offer the chance to improve drug transport and delivery through biological barriers, exploiting the possibility to leave the blood circulation and traverse the endothelial vascular bed, blood-brain barrier (BBB) included, to reach their target. It is known that nanoparticles gather molecules on their surface upon contact with biological fluids, forming the protein corona, which can affect their fate and therapeutic/diagnostic performance, yet no information on the corona's evolution across the barrier has been gathered so far. Using a cellular model of the BBB and gold nanoparticles, we show that the composition of the corona undergoes dramatic quantitative and qualitative molecular modifications during passage from the blood to the brain side, while it is stable once beyond the BBB. Thus, we demonstrate that the nanoparticle corona dynamically and drastically evolves upon crossing the BBB and that its initial composition is not predictive of nanoparticle fate and performance once beyond the barrier at the target organ.
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