期刊
ACS NANO
卷 12, 期 4, 页码 3699-3713出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b00893
关键词
magnetic particle imaging; magnetic nanoparticles; superparamagnetic iron oxide nanoparticles; magnetic hyperthermia; magnetic fluid hyperthermia; image-guided; theranostics; targeted therapy
类别
资金
- NIH Grants [R01 EB019458, EB024578]
- UC TRDRP Grant [26IP-0049]
- M. Cook Chair
- UC Discovery Award
- NIH [1R21 EB018453-01A1, 1R43 DA041814-01A1, 5R43 EB020463-02]
- University of Florida Health Cancer Center
- Siebel Scholars Foundation
- Agency of Science Technology and Research, Singapore
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB019458, R43EB020463, R01EB024578, R21EB018453] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R43DA041814] Funding Source: NIH RePORTER
Image-guided treatment of cancer enables physicians to localize and treat tumors with great precision. Here, we present in vivo results showing that an emerging imaging modality, magnetic particle imaging (MPI), can be combined with magnetic hyperthermia into an image-guided theranostic platform. MPI is a noninvasive 3D tomographic imaging method with high sensitivity and contrast, zero ionizing radiation, and is linearly quantitative at any depth with no view limitations. The same superparamagnetic iron oxide nanoparticle (SPIONs) tracers imaged in MPI can also be excited to generate heat for magnetic hyperthermia. In this study, we demonstrate a theranostic platform, with quantitative MPI image guidance for treatment planning and use of the MPI gradients for spatial localization of magnetic hyperthermia to arbitrarily selected regions. This addresses a key challenge of conventional magnetic hyperthermia SPIONs delivered systemically accumulate in off-target organs (e.g., liver and spleen), and difficulty in localizing hyperthermia results in collateral heat damage to these organs. Using a MPI magnetic hyperthermia workflow, we demonstrate image-guided spatial localization of hyperthermia to the tumor while minimizing collateral damage to the nearby liver (1-2 cm distance). Localization of thermal damage and therapy was validated with luciferase activity and histological assessment. Apart from localizing thermal therapy, the technique presented here can also be extended to localize actuation of drug release and other biomechanical-based therapies. With high contrast and high sensitivity imaging combined with precise control and localization of the actuated therapy, MPI is a powerful platform for magnetic-based theranostics.
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