期刊
ACS NANO
卷 12, 期 5, 页码 4086-4095出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b02758
关键词
-
类别
资金
- Harvard University
- Organ Design and Engineering Postdoctoral Training (ODET) through Brigham and Women's Hospital
- National Institute of Health [5-T32-EB016652-04]
- Air Force Office of Scientific Research [AFOSR FA9550-15-1-0285]
- National Institutes of Health [NIH NS101488]
- National Institute of Biomedical Imaging and Bioengineering (NBIB)
The ability to probe and modulate electrical signals sensitively at cellular length scales is a key challenge in the field of electrophysiology. Electrical signals play integral roles in regulating cellular behavior and in controlling biological function. From cardiac arrhythmias to neurodegenerative disorders, maladaptive phenotypes in electrophysiology can result in serious and potentially deadly medical conditions. Understanding how to monitor and to control these behaviors precisely and noninvasively represents an important step in developing next-generation therapeutic devices. As we develop a deeper understanding of neural network formation, electrophysiology has the potential to offer fundamental insights into the inner working of the brain. In this Perspective, we explore traditional methods for examining neural function, discuss recent genetic advances in electrophysiology, and then focus on the latest innovations in optical sensing and stimulation of action potentials in neurons. We emphasize nongenetic optical methods, as these provide high spatiotemporal resolution and can be achieved with minimal invasiveness.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据