期刊
ACS NANO
卷 12, 期 5, 页码 4362-4368出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b09189
关键词
infrared bioimaging; in vivo multiplexing; rare-earth-doped nanoparticles; lifetime spectroscopy; biological windows
类别
资金
- Spanish Ministry of Economy and Competitiveness
- Spanish National Health Insitutue (Institute de Salud Carlos III)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- CNPq (Conselho Nacional de Desenvolvimento Cientifico de Tecnologico)
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities, China
Advanced diagnostic procedures are required to satisfy the continuously increasing demands of modern biomedicine while also addressing the need for cost reduction in public health systems. The development of infrared luminescence-based techniques for in vivo imaging as reliable alternatives to traditional imaging enables applications with simpler and more cost-effective apparatus. To further improve the information provided by in vivo luminescence images, the design and fabrication of enhanced infrared-luminescent contrast agents is required. In this work, we demonstrate how simple dopant engineering can lead to infrared-emitting rare-earth doped nanoparticles with tunable (0.1-1.5 ms) and medium-independent luminescence lifetimes. The combination of these tunable nanostructures with time-gated infrared imaging and time domain analysis is employed to obtain multiplexed in vivo images that are used for complex biodistribution studies.
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