期刊
ACS NANO
卷 12, 期 5, 页码 4761-4774出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b01470
关键词
serotonin; polydopamine; protein corona; drug delivery; nano-bio interface; mass spectrometry; quantum mechanics; molecular dynamics
类别
资金
- Cal-Brain Neurotechnology Program
- National Institute on Drug Abuse [DA045550]
- National Institute of Dental and Craniofacial Research [DE023825]
- National Institute of Allergy and Infectious Disease (UCLA/CFAR Virology Core Lab) [AI028697]
Serotonin-based nanoparticles represent a class of previously unexplored multifunctional nanoplatforms with potential biomedical applications. Serotonin, under basic conditions, self-assembles into monodisperse nanoparticles via autoxidation of serotonin monomers. To demonstrate potential applications of polyserotonin nanoparticles for cancer therapeutics, we show that these particles are biocompatible, exhibit photothermal effects when exposed to near-infrared radiation, and load the chemotherapeutic drug doxorubicin, releasing it contextually and responsively in specific microenvironments. Quantum mechanical and molecular dynamics simulations were performed to interrogate the interactions between surface-adsorbed drug molecules and polyserotonin nano particles. To investigate the potential of polyserotonin nanoparticles for in vivo targeting, we explored their nano bio interfaces by conducting protein corona experiments. Polyserotonin nanoparticles had reduced surface-protein interactions under biological conditions compared to polydopamine nanoparticles, a similar polymer material widely investigated for related applications. These findings suggest that serotonin-based nanoparticles have advantages as drug-delivery platforms for synergistic chemo- and photothermal therapy associated with limited nonspecific interactions.
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