期刊
ACS CHEMICAL NEUROSCIENCE
卷 9, 期 3, 页码 421-430出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.7b00462
关键词
Myeloperoxidase; neuroinflammation; neuroprotection
资金
- Department of Science and Technology (DST), Govt.of India [SB/YS/LS-196/2014]
- Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
- NIPER Ahmedabad
Myeloperoxidase (MPO) is a protein present in azurophilic granules, macrophages, and neutrophils that are released into extracellular fluid (ECF) during inflammation. MPO releases hypochlorous acid (HOC and other chlorinated species. It is derived from hydrogen peroxide (H2O2) showing response during inflammatory conditions and plays a role in the immune defense against pathogens. MPO may show unwanted effects by indirectly increasing the formation of reactive nitrogen species (RNS), reactive oxygen species (ROS), and tumor necrosis factor alpha (TNF-alpha) leading to inflammation and oxidative stress. As neuroinflammation is one of the inevitable biological components among most of neurological disorders, MPO and its receptor may be explored as candidates for future clinical interventions. The purpose of this review is to provide an overview of the pathophysiological characteristics of MPO and further explore the possibilities to target it for clinical use. Targeting MPO is promising and may open an avenue to act as a biomarker for diagnosis with defined risk stratification in patients with various neurological disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据